AUTHOR=Vieira Alexandre R. , Modesto Adriana TITLE=Oral microbiome dental caries associated genotypes analysis of 6- to 19-year-old individuals shows novel associations JOURNAL=Frontiers in Dental Medicine VOLUME=3 YEAR=2022 URL=https://www.frontiersin.org/journals/dental-medicine/articles/10.3389/fdmed.2022.875953 DOI=10.3389/fdmed.2022.875953 ISSN=2673-4915 ABSTRACT=
The need to determine risk factors for complex diseases continues to drive efforts to identify etiological factors of common conditions. Molecular tools have created new opportunities to identify risk factors that may act interactively. The goal of this work was to explore potential interactions between oral microbial species and common genetic variants. Ninety-two 6- to 19-year-old individuals recruited through the University of Pittsburgh Dental Registry and DNA Repository project that had oral microbiome and genotyping of 44 single nucleotide polymorphism (SNP) data available were studied. Over-representation of alleles between individuals with or without particular microorganisms was determined using chi-square or Fisher's exact tests. An alpha of 0.001, to account for multiple testing (0.05/44), was considered statistically significant. Associations were found between