AUTHOR=Meyer Frederic , Enax Joachim , Amaechi Bennett Tochukwu , Limeback Hardy , Fabritius Helge-Otto , Ganss Bernhard , Pawinska Malgorzata , Paszynska Elzbieta TITLE=Hydroxyapatite as Remineralization Agent for Children's Dental Care JOURNAL=Frontiers in Dental Medicine VOLUME=3 YEAR=2022 URL=https://www.frontiersin.org/journals/dental-medicine/articles/10.3389/fdmed.2022.859560 DOI=10.3389/fdmed.2022.859560 ISSN=2673-4915 ABSTRACT=
Children are prone to develop dental caries. This is supported by epidemiological data confirming early childhood caries (ECC) as a highly prevalent disease affecting more than every second child worldwide. ECC is known to result from an imbalance between re- and demineralization where demineralization dominates due to frequent acid production by cariogenic bacteria present in oral biofilms. The application of oral care formulations containing remineralizing agents helps to prevent dental caries. As young children are sensitive and usually swallow (intended or unintended) a majority of toothpaste or other oral care products during daily dental care, all ingredients, especially the actives, should be non-toxic. Biomimetic hydroxyapatite [HAP; Ca5(PO4)3(OH)] is known to have favorable remineralizing properties combined with an excellent biocompatibility, i.e., it is safe if accidently swallowed. Several clinical trials as well as