AUTHOR=Yan Chaoting , Yu Jinhua TITLE=Noncoding RNA in Extracellular Vesicles Regulate Differentiation of Mesenchymal Stem Cells JOURNAL=Frontiers in Dental Medicine VOLUME=2 YEAR=2022 URL=https://www.frontiersin.org/journals/dental-medicine/articles/10.3389/fdmed.2021.806001 DOI=10.3389/fdmed.2021.806001 ISSN=2673-4915 ABSTRACT=

To achieve the desired outcome in tissue engineering regeneration, mesenchymal stem cells need to undergo a series of biological processes, including differentiating into the ideal target cells. The extracellular vesicle (EV) in the microenvironment contributes toward determining the fate of the cells with epigenetic regulation, particularly from noncoding RNA (ncRNA), and exerts transportation and protective effects on ncRNAs. We focused on the components and functions of ncRNA (particularly microRNA) in the EVs. The EVs modified by the ncRNA favor tissue regeneration and pose a potential challenge.