Sou Nobukawa1,2,3,4*
Tetsuya Takahashi5,6,7- 1Graduate School of Information and Computer Science, Chiba Institute of Technology, Narashino, Japan
- 2Department of Computer Science, Chiba Institute of Technology, Narashino, Japan
- 3Research Centre for Mathematical Engineering, Chiba Institute of Technology, Narashino, Japan
- 4Department of Preventive Intervention for Psychiatric Disorders, National Institute of Medicine Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan
- 5Research Centre for Child Mental Development, Kanazawa University, Kanazawa, Japan
- 6Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, Yoshida, Japan
- 7Uozu Shinkei Sanatorium, Uozu, Japan
Editorial on the Research Topic
Perspectives in brain-network dynamics in computational psychiatry
1. Introduction
The cognitive functions of the brain are achieved through mutual interactions between various hierarchical regional neural activities (reviewed in Sporns, 2016). Throughout the current decade, studies on brain networks have revealed the dynamical behaviors of brain networks, including multitemporal scale dynamics, from ultra-slow to moment-to-moment behaviors (Ando et al., 2021, 2022; Iinuma et al., 2022; Gandhi et al.) (reviewed in Garrett et al., 2013; Takahashi, 2013; Palva and Palva, 2018). In these multiscale neural activities, the network dynamics, which is captured by the degree of synchronization and information flow between pair-wise brain regional neural activities [called dynamic functional connectivity (dFC)], play an important role in coordinating the mutual interactions of neural activities (reviewed in Cohen, 2018; Luppi et al., 2022). Moreover, besides the pair-wise neural interactions, the temporal itinerancy of the global topology of the whole-brain functional network is present (Guan et al., 2022). Under pathological conditions, the multitemporal scale characteristics of such network dynamics exhibit disease-specific alternations (Yan et al., 2023). These characteristics therefore pose the possibility of realizing potential biomarkers to identify psychiatric disorders. For achieving this, we have two major approaches.
The first is a physiological data-driven neuroimaging approach using electroencephalography (EEG), magnetoencephalography (MEG), and functional magnetic resonance imaging (fMRI). For this approach, the method for utilizing the temporal variation of functional connectivity within a short time window has been developed (Damaraju et al., 2014). Subsequently, a more rigid method for determining the length of a window based on the temporal transition of a quasistable spatial power distribution, called a microstate, was proposed (Guan et al., 2022; Yan et al., 2023). Moreover, instead of focusing on synchronization within the time-window, a technique of utilizing the instantaneous temporal patterns produced by neural interaction was also developed, which is required for achieving high temporal resolution to capture the characteristics of moment-to-moment dynamical functional connectivity (Nobukawa et al., 2019).
The second approach is a simulation-based one using mathematical models with high pathological validity, typified as abstract whole-brain neural networks and spiking neural networks (reviewed in Cabral et al., 2017; Nobukawa, 2022). Recent mathematical modeling of brain networks focuses on large hierarchical neural characteristics from the molecular/cellular and local neural circuit levels to the global whole brain level. Therefore, embedding disease-specific impairments into the modeled-brain network studies could reveal the mechanisms by which these individual impairments affect the alternations of brain network dynamics (Matsumoto et al., 2023; Park et al.; Zhu et al.).
This Research Topic is intended to inspire further research focusing on both approaches, and to facilitate the mutual use of the findings of network dynamics and individual approaches. This editorial briefly explains the studies based on these approaches.
2. Network dynamics in the physiological-data approach
Studies in this decade have revealed that functional connectivity exhibits large temporal variability, even in the resting state, which is called dFC (Betzel et al., 2012; Hutchison et al., 2013; Allen et al., 2014; Calhoun et al., 2014; Hansen et al., 2015) (reviewed in Cohen, 2018). These network dynamics possess quasistable states, temporal transitions, and hierarchical sequential characteristics (Vidaurre et al., 2017), instead of random characteristics. These dynamical characteristics strongly relate to cognitive functions [e.g., executive functions (Braun et al., 2015), associative learning (Bassett et al., 2011), perceptions (Frolov et al., 2019), and deficits in cognitive functions in various pathological conditions such as, schizophrenia (Damaraju et al., 2014), autism (Guo et al., 2020), and Alzheimer's disease (Gu et al., 2020)] (reviewed in Gonzalez-Castillo and Bandettini, 2018; Sporns, 2022). In this Research Topic, Gandhi et al. specifically evaluated neurophysiological differentiation as a measure of dynamical network states related to the subjective perception of visual stimuli. Notably, despite the use of neuropixels recordings as an invasive method, these findings could potentially aid in the identification of biomarkers for psychiatric disorders characterized by dysfunctional perceptual processes.
3. Network dynamics in the simulation-based approach
In addition to the experimental studies based on physiological data, the simulation-based approach with mathematical modeling is effective for revealing factors that induce the alteration of network dynamics by embedding the network structural characteristics into the neural networks (Lea-Carnall et al.; Barkdoll et al.; Park et al.; Zhu et al.) (reviewed in D'Angelo and Jirsa, 2022). Particularly, in this Research Topic, Lea-Carnall et al. demonstrated that dynamical network patterns appear according to the fluctuation level, which is suggestive of dFC. Furthermore, it is widely recognized that an imbalance of excitatory and inhibitory neural activity leads to abnormal neural activity observed under pathological conditions and deficits in cognitive function (reviewed in Yizhar et al., 2011; Bosman et al., 2014). Park et al. reported that a locally increased excitatory/inhibitory ratio prevents information flow in neural networks; subsequently, the complexity as the degree of mutual interactions among neural populations reduces, and Zhu et al. further demonstrated that the deficits of top-down control and inhibitory effects lead to a schizophrenia-like illusion representation. Barkdoll et al. constructed a neural network model for the emergence of binocular rivalry and showed that impairment of inhibitory neural activity leads to the slow percept switching in binocular rivalry, which resembles the tendency observed in autism.
4. Conclusions
In this editorial, we have explained several recent studies, particularly including those acquired studies in this Research Topic (Lea-Carnall et al.; Gandhi et al.; Barkdoll et al.; Park et al.; Zhu et al.), for network dynamics using physiological-data and simulation-based approaches. We believe that the findings of these studies will interact to facilitate future biomarker development for psychiatric disorders.
Author contributions
SN: Writing—original draft, Writing—review and editing. TT: Writing—original draft, Writing—review and editing.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's note
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Keywords: models, network dynamics, neural circuits, multi-temporal scale, neuroimaging, psychiatry
Citation: Nobukawa S and Takahashi T (2023) Editorial: Perspectives in brain-network dynamics in computational psychiatry. Front. Comput. Neurosci. 17:1290089. doi: 10.3389/fncom.2023.1290089
Received: 06 September 2023; Accepted: 11 September 2023;
Published: 22 September 2023.
Edited and reviewed by: Si Wu, Peking University, China
Copyright © 2023 Nobukawa and Takahashi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Sou Nobukawa, nobukawa@cs.it-chiba.ac.jp