AUTHOR=Fosque Leandro J. , Alipour Abolfazl , Zare Marzieh , Williams-García Rashid V. , Beggs John M. , Ortiz Gerardo TITLE=Quasicriticality explains variability of human neural dynamics across life span JOURNAL=Frontiers in Computational Neuroscience VOLUME=16 YEAR=2022 URL=https://www.frontiersin.org/journals/computational-neuroscience/articles/10.3389/fncom.2022.1037550 DOI=10.3389/fncom.2022.1037550 ISSN=1662-5188 ABSTRACT=

Aging impacts the brain's structural and functional organization and over time leads to various disorders, such as Alzheimer's disease and cognitive impairment. The process also impacts sensory function, bringing about a general slowing in various perceptual and cognitive functions. Here, we analyze the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) resting-state magnetoencephalography (MEG) dataset—the largest aging cohort available—in light of the quasicriticality framework, a novel organizing principle for brain functionality which relates information processing and scaling properties of brain activity to brain connectivity and stimulus. Examination of the data using this framework reveals interesting correlations with age and gender of test subjects. Using simulated data as verification, our results suggest a link between changes to brain connectivity due to aging and increased dynamical fluctuations of neuronal firing rates. Our findings suggest a platform to develop biomarkers of neurological health.