AUTHOR=Shaheen Hina , Singh Sundeep , Melnik Roderick 

TITLE=A Neuron-Glial Model of Exosomal Release in the Onset and Progression of Alzheimer's Disease

JOURNAL=Frontiers in Computational Neuroscience

VOLUME=15

YEAR=2021

URL=https://www.frontiersin.org/journals/computational-neuroscience/articles/10.3389/fncom.2021.653097

DOI=10.3389/fncom.2021.653097

ISSN=1662-5188

ABSTRACT=<p>Exosomes are nano-sized extracellular vesicles that perform a variety of biological functions linked to the pathogenesis of various neurodegenerative disorders. In Alzheimer's disease (AD), for examples, exosomes are responsible for the release of <italic>Aβ</italic> oligomers, and their extracellular accumulation, although the underpinning molecular machinery remains elusive. We propose a novel model for Alzheimer's <italic>Aβ</italic> accumulation based on <italic>Ca</italic><sup>2+</sup>-dependent exosome release from astrocytes. Moreover, we exploit our model to assess how temperature dependence of exosome release could interact with <italic>Aβ</italic> neurotoxicity. We predict that voltage-gated <italic>Ca</italic><sup>2+</sup> channels (VGCCs) along with the transient-receptor potential M8 (TRPM8) channel are crucial molecular components in Alzheimer's progression.</p>