AUTHOR=Yuan Quan , Xu Jieqiong , Chen Huiying 

TITLE=Dynamics Analysis of Firing Patterns in Pre-Bötzinger Complex Neurons Model

JOURNAL=Frontiers in Computational Neuroscience

VOLUME=15

YEAR=2021

URL=https://www.frontiersin.org/journals/computational-neuroscience/articles/10.3389/fncom.2021.591037

DOI=10.3389/fncom.2021.591037

ISSN=1662-5188

ABSTRACT=<p>Pre-Bötzinger complex (PBC) neurons located in mammalian brain are the necessary conditions to produce respiratory rhythm, which has been widely verified experimentally and numerically. At present, one of the two different types of bursting mechanisms found in PBC mainly depends on the calcium-activated of non-specific cation current (<italic>I</italic><sub><italic>CaN</italic></sub>). In order to study the influence of <italic>I</italic><sub><italic>CaN</italic></sub> and stimulus current <italic>I</italic><sub><italic>exc</italic></sub> in PBC inspiratory neurons, a single compartment model was simplified, and firing patterns of the model was discussed by using stability theory, bifurcation analysis, fast, and slow decomposition technology combined with numerical simulation. Under the stimulation of different somatic applied currents, the firing behavior of neurons are studied and exhibit multiple mix bursting patterns, which is helpful to further understand the mechanism of respiratory rhythms of PBC neurons.</p>