AUTHOR=Chen Mingming , Guo Daqing , Xia Yang , Yao Dezhong 

TITLE=Control of Absence Seizures by the Thalamic Feed-Forward Inhibition

JOURNAL=Frontiers in Computational Neuroscience

VOLUME=11

YEAR=2017

URL=https://www.frontiersin.org/journals/computational-neuroscience/articles/10.3389/fncom.2017.00031

DOI=10.3389/fncom.2017.00031

ISSN=1662-5188

ABSTRACT=<p>As a subtype of idiopathic generalized epilepsies, absence epilepsy is believed to be caused by pathological interactions within the corticothalamic (CT) system. Using a biophysical mean-field model of the CT system, we demonstrate here that the feed-forward inhibition (FFI) in thalamus, i.e., the pathway from the cerebral cortex (Ctx) to the thalamic reticular nucleus (TRN) and then to the specific relay nuclei (SRN) of thalamus that are also directly driven by the Ctx, may participate in controlling absence seizures. In particular, we show that increasing the excitatory Ctx-TRN coupling strength can significantly suppress typical electrical activities during absence seizures. Further, investigation demonstrates that the GABA<sub>A</sub>- and GABA<sub>B</sub>-mediated inhibitions in the TRN-SRN pathway perform combination roles in the regulation of absence seizures. Overall, these results may provide an insightful mechanistic understanding of how the thalamic FFI serves as an intrinsic regulator contributing to the control of absence seizures.</p>