AUTHOR=Kobayashi Ryota , He Jufang , Lansky Petr TITLE=Estimation of the synaptic input firing rates and characterization of the stimulation effects in an auditory neuron JOURNAL=Frontiers in Computational Neuroscience VOLUME=9 YEAR=2015 URL=https://www.frontiersin.org/journals/computational-neuroscience/articles/10.3389/fncom.2015.00059 DOI=10.3389/fncom.2015.00059 ISSN=1662-5188 ABSTRACT=

To understand information processing in neuronal circuits, it is important to infer how a sensory stimulus impacts on the synaptic input to a neuron. An increase in neuronal firing during the stimulation results from pure excitation or from a combination of excitation and inhibition. Here, we develop a method for estimating the rates of the excitatory and inhibitory synaptic inputs from a membrane voltage trace of a neuron. The method is based on a modified Ornstein-Uhlenbeck neuronal model, which aims to describe the stimulation effects on the synaptic input. The method is tested using a single-compartment neuron model with a realistic description of synaptic inputs, and it is applied to an intracellular voltage trace recorded from an auditory neuron invivo. We find that the excitatory and inhibitory inputs increase during stimulation, suggesting that the acoustic stimuli are encoded by a combination of excitation and inhibition.