AUTHOR=Segovia Fermín , Holt Rosemary , Spencer Michael , Górriz Juan M. , Ramírez Javier , Puntonet Carlos G. , Phillips Christophe , Chura Lindsay , Baron-Cohen Simon , Suckling John TITLE=Identifying endophenotypes of autism: a multivariate approach JOURNAL=Frontiers in Computational Neuroscience VOLUME=8 YEAR=2014 URL=https://www.frontiersin.org/journals/computational-neuroscience/articles/10.3389/fncom.2014.00060 DOI=10.3389/fncom.2014.00060 ISSN=1662-5188 ABSTRACT=
The existence of an endophenotype of autism spectrum condition (ASC) has been recently suggested by several commentators. It can be estimated by finding differences between controls and people with ASC that are also present when comparing controls and the unaffected siblings of ASC individuals. In this work, we used a multivariate methodology applied on magnetic resonance images to look for such differences. The proposed procedure consists of combining a searchlight approach and a support vector machine classifier to identify the differences between three groups of participants in pairwise comparisons: controls, people with ASC and their unaffected siblings. Then we compared those differences selecting spatially collocated as candidate endophenotypes of ASC.