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ORIGINAL RESEARCH article

Front. Coat. Dyes Interface Eng.
Sec. Soft Coatings
Volume 3 - 2025 | doi: 10.3389/frcdi.2025.1531144

Doxorubicin and Sorafenib release from mesoporous silica nanoparticles coated with polydopamineinfluence of mechanical and chemical stimuli on the process

Provisionally accepted
Sylwia Ostrowska Sylwia Ostrowska 1Monika Szukowska Monika Szukowska 1Shinki Kim Shinki Kim 2Yeonho Kim Yeonho Kim 2Dariusz Wawrzyniak Dariusz Wawrzyniak 3Radosław Mrówczyński Radosław Mrówczyński 1*
  • 1 Adam Mickiewicz University, Poznań, Poland
  • 2 Konkuk University, Seoul, Seoul, Republic of Korea
  • 3 Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Greater Poland, Poland

The final, formatted version of the article will be published soon.

    In this paper, we present results of a study on the influence of different experimental conditions on drug release, for the two anticancer drugs: doxorubicin (DOX) and sorafenib (SO), from mesoporous silica nanoparticles coated with polydopamine (PDA) shell. We tested the drugs release from the carrier into buffers of different pH (4.5; 5.5; 7.5) and with the addition of H2O2 or glutathione (GSH), while stirring the carriers in a flask or shaking them in a thermoblock, keeping the same time intervals, temperature and frequency. The obtained results and performed statistical analysis prove that the way the drug release tests are conducted has a significant influence on the efficiency of release of both drugs from the carrier. Thus, our results are of great importance for characterization of multimodal nanocarriers for biomedical application in terms of drug release and bring new knowledge for their methodological investigation.

    Keywords: polydopamine, drug release, Silica nanoparticles, Sorafenib, Doxorubicin

    Received: 19 Nov 2024; Accepted: 24 Jan 2025.

    Copyright: © 2025 Ostrowska, Szukowska, Kim, Kim, Wawrzyniak and Mrówczyński. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Radosław Mrówczyński, Adam Mickiewicz University, Poznań, Poland

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.