AUTHOR=Panfili Eleonora , Frontino Giulio , Pallotta Maria Teresa TITLE=GLP-1 receptor agonists as promising disease-modifying agents in WFS1 spectrum disorder JOURNAL=Frontiers in Clinical Diabetes and Healthcare VOLUME=4 YEAR=2023 URL=https://www.frontiersin.org/journals/clinical-diabetes-and-healthcare/articles/10.3389/fcdhc.2023.1171091 DOI=10.3389/fcdhc.2023.1171091 ISSN=2673-6616 ABSTRACT=
WFS1 spectrum disorder (WFS1-SD) is a rare monogenic neurodegenerative disorder whose cardinal symptoms are childhood-onset diabetes mellitus, optic atrophy, deafness, diabetes insipidus, and neurological signs ranging from mild to severe. The prognosis is poor as most patients die prematurely with severe neurological disabilities such as bulbar dysfunction and organic brain syndrome. Mutation of the