95% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
MINI REVIEW article
Front. Chem.
Sec. Medicinal and Pharmaceutical Chemistry
Volume 13 - 2025 | doi: 10.3389/fchem.2025.1571067
This article is part of the Research Topic Quinoline as Lead Structures for the Development of Leishmanicidal Agents View all 3 articles
The quinoline framework and related scaffolds in natural products with anti-Leishmania properties
Provisionally accepted- 1 Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunción, San Lorenzo, Paraguay
- 2 Center for the Development of Scientific Research (CEDIC), Asuncion, Paraguay
- 3 Universidad de la República, Montevideo, Uruguay
- 4 Faculty of Sciences, University of the Republic, Montevideo, Uruguay
For almost hundred years, the quinoline heterocycle has been recognized as a privileged pharmacophore in anti-Leishmania agents. Early on, the action of compounds with this scaffold, found in some natural alkaloids, was evidenced against different Leishmania stages and strains. Different structural arrangements containing quinoline framework have been described in different in vitro and in vivo anti-Leishmania alkaloids, namely quinoline proper, isoquinoline, quinolone, among others. In recent years, new quinoline-derivatives isolated from nature have been described, in addition to having carried out in-depth biological studies, in vitro and in vivo, as well as chemical modifications to obtain new leaders. This review updates the state of the art on naturally occurring quinolines and some synthetic derivatives to provide therapeutic tools and strategies to explore new drugs based on this chemosystem for the treatment of leishmaniasis.
Keywords: 2-substitutedquinoline, Furoquinoline, Polyhydroquinoline, Bisbenzylisoquinoline, Quinolinone
Received: 04 Feb 2025; Accepted: 27 Mar 2025.
Copyright: © 2025 Yaluff, Herrera, Rolon, Vega and Cerecetto. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hugo Cerecetto, Universidad de la República, Montevideo, Uruguay
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.