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ORIGINAL RESEARCH article
Front. Chem.
Sec. Organic Chemistry
Volume 13 - 2025 | doi: 10.3389/fchem.2025.1558075
This article is part of the Research Topic Isolation, Structural Elucidation, and Biological Evaluation of Bioactive Products from Traditional Medicine-Volume II View all 4 articles
Iridoid Glycoside Dimers from Fruits of Cornus officinalis and Their Anti-inflammatory Activity
Provisionally accepted- 1 Beijing University of Chinese Medicine, Beijing, Beijing Municipality, China
- 2 Beijing Union University, Beijing, China
- 3 Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, Beijing Municipality, China
The bioassay-guided phytochemical study on fruits of Cornus officinalis led to the isolation of six new iridoid glycoside dimers, named corndiridoside A-F (1-6), together with 11 analogues (7-17). Their structures were elucidated by HRESIMS, 1D and 2D NMR, IR, UV spectra and literatures. The antiinflammatory activity of all compounds was determined, and the results showed that all compounds had a significant inhibitory effect on the production of NO in LPS-stimulated RAW 264.7 cells at concentrations of 25 and 50 μM, among which compounds 2 and 3 showed the strongest antiinflammatory activity.
Keywords: Cornus officinalis, iridoid glycoside dimers, Isolation, structure identification, Antiinflammatory activity
Received: 09 Jan 2025; Accepted: 19 Feb 2025.
Copyright: © 2025 Shi, Yu, Gao, Wang, Shang and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jia Xu, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, Beijing Municipality, China
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