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REVIEW article

Front. Chem.
Sec. Analytical Chemistry
Volume 13 - 2025 | doi: 10.3389/fchem.2025.1548364

Coupling of chromatography with surface-enhanced Raman spectroscopy: trends and prospects

Provisionally accepted
Ekaterina V. Dmitrieva Ekaterina V. Dmitrieva 1,2*Olesya O. Kapitanova Olesya O. Kapitanova 2Shixian Lv Shixian Lv 3Oleg G. Sinyashin Oleg G. Sinyashin 4Irina A. Veselova Irina A. Veselova 2,5
  • 1 Faculty of Material Sciences, Shenzhen MSU-BIT University, Shenchzhen, China
  • 2 Chemistry Department, Lomonosov Moscow State University, Moscow, Moscow, Russia
  • 3 School of Materials Science and Engineering, Peking University, Beijing, Beijing Municipality, China
  • 4 Kazan Scientific Center (RAS), Kazan, Tatarstan, Russia
  • 5 Faculty of Material Sciiences, Shenzhen MSU-BIT University, Shenchzhen, China

The final, formatted version of the article will be published soon.

    Surface-enhanced Raman spectroscopy is a powerful analytical technique for the determination of analytes with the advantages of sensitivity, portability, and simplicity, able to provide structural information for the identification of compounds. However, when it comes to the analysis of complex samples, matrix components may interfere with the analyte quantification. To overcome this shortcoming, a number of approaches have been proposed, such as extraction techniques. Among them, the coupling of chromatography with surface-enhanced Raman spectroscopy seems to be promising. It allows combining the advantages of both techniques, i.e., high efficiency of chromatographic separation and high sensitivity of SERS detection, and makes possible simultaneous quantification of multiple analytes. The review summarizes the latest achievements in the combination of these techniques.

    Keywords: surface-enhanced Raman spectroscopy, Chromatography, TLC-SERS, HPLC-SERS, method development

    Received: 19 Dec 2024; Accepted: 04 Feb 2025.

    Copyright: © 2025 Dmitrieva, Kapitanova, Lv, Sinyashin and Veselova. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ekaterina V. Dmitrieva, Faculty of Material Sciences, Shenzhen MSU-BIT University, Shenchzhen, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.