Construction of pH-Responsive Hydrogel Coatings on Titanium Surfaces for Antibacterial and Osteogenic Properties

Shan Peng ^1,2 Yueru Liu ^1,2 Wei Zhao ^1,2 Xinpeng Liu ^1,2 Ronghua Yu ^1,2 Yonglin Yu ^1,2*

• ¹ Department of Pathology, Affiliated hospital of Zunyi Medical University, Zunyi, China
• ² Department of Pathophysiology, Zunyi Medical University, Zunyi, Guizhou Province, China

Infection is one of the leading causes of failure in titanium-based implant materials during clinical surgeries, often resulting in delayed or non-union of bone healing. Furthermore, the overuse of antibiotics can lead to bacterial resistance. Therefore, developing a novel titanium-based implant material with both antimicrobial and osteogenic properties is of great significance. In this study, chitosan (CS), polydopamine (PDA), and antimicrobial peptides (AMPs) HHC36 were applied to modify the surface of titanium, resulting in the successful preparation of the composite material Ti-PDA-CS/PDA@HHC36 (abbreviated as T-P-C/P@H). CS promotes osteogenesis and cell adhesion, providing an ideal microenvironment for bone repair. PDA enhances the material's biocompatibility and corrosion resistance, offering cell adhesion sites, while both components exhibit pH-responsive characteristics. The HHC36 effectively prevents infection, protecting the bone repair material from bacterial damage. Overall, the synergistic effects of these components in T-P-C/P@H not only confer excellent antimicrobial and osteogenic properties but also improve biocompatibility, offering a new strategy for applying titanium-based implants in clinical settings.