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ORIGINAL RESEARCH article

Front. Chem.
Sec. Supramolecular Chemistry
Volume 13 - 2025 | doi: 10.3389/fchem.2025.1545850
This article is part of the Research Topic Supramolecular Cancer Therapeutic Biomaterials-Volume II View all 4 articles

Resveratrol-loaded metal-organic framework for mitochondriatargeted amplified CO gas therapy

Provisionally accepted
Fengqin Wang Fengqin Wang Yingfang Jiang Yingfang Jiang Yang Wang Yang Wang *
  • Nantong Institute of Technology (NIT), Nantong, Jiangsu Province, China

The final, formatted version of the article will be published soon.

    Carbon monoxide (CO) based gas therapy has recently garnered significant attention due to its remarkable therapeutic effects for various major diseases. However, the primary challenge in gas therapy is the effective delivery of gas prodrug to targeted sites, as well as achieving precise spatialtemporal control over their release behavior. In this work, we provide a facile method to design ROSresponsive and mitochondrial targeting CO-delivery nanoplatform, based on the thiol-functionalized metal-organic framework (MOF), abbreviated as UiO-66-SH, incorporating the drug resveratrol (RES) for combined tumor therapy. After endocytosis by tumor cells and localization within the mitochondria, UiO@FeCO@RES was decomposed by ATP to release RES and generate CO gas via a Fenton-like reaction between hydroxyl radicals (• OH) and FeCO. RES acts as an ATPase inhibitor, disrupting the metabolism of the respiratory chain in tumor cell and thereby facilitating ATP-blocked metabolic therapy. In vitro experimental results demonstrate that the combination therapy, involving both RES drug and CO gas therapy, exhibits a synergistic effect against cancer cells. This synergistic strategy has endowed UiO@FeCO@RES as a promising material for biomedical applications.

    Keywords: metal-organic framework1, mitochondria-targeting2, Reactive Oxygen Species3, combined therapy4, gas therapy5

    Received: 16 Dec 2024; Accepted: 02 Jan 2025.

    Copyright: © 2025 Wang, Jiang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yang Wang, Nantong Institute of Technology (NIT), Nantong, Jiangsu Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.