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REVIEW article
Front. Chem.
Sec. Organic Chemistry
Volume 13 - 2025 | doi: 10.3389/fchem.2025.1527387
This article is part of the Research Topic Recent Advances in Synthetic Organic Chemistry at the Biomedical Interface: Honoring Professor Iwao Ojima on the Occasion of his 80th Birthday View all 6 articles
Application of Hosomi-Sakurai Allylation Reaction in Total Synthesis of Biologically Active Natural Products
Provisionally accepted- University of Ghana, Accra, Ghana
The Hosomi-Sakurai allylation reaction has been widely applied in the total synthesis of biologically active natural products, especially in synthesising complex polycyclic compounds containing multi-stereogenic centres since its discovery in 1976. The Hosomi-Sakurai allylation is the allylation of ketones and aldehyde with nucleophilic allylsilanes catalyzed with Lewis acid mainly used to extend the C-C bond in a molecule and also create a new site for manipulation due to the facile transformation of the pi (π) bond at the end of its chain. This review highlights only portions of natural product synthetic works that feature the Hosomi-Sakurai allylation reaction or its modification as a key transformation in the synthetic route.
Keywords: Hosomi-Sakurai allylation, carbonylation, Total synthesis, stereoselectivity, Natural Products, Lewis acid-promotors 2.12 Total syntheses of Grayanane Diterpenoids: (-)-Grayanotoxin III, (+)-Principinol E, and
Received: 13 Nov 2024; Accepted: 28 Feb 2025.
Copyright: © 2025 Amewu, Akwensi, Kumah and Osei-Safo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Richard Kwamla Amewu, University of Ghana, Accra, Ghana
Dorcas Osei-Safo, University of Ghana, Accra, Ghana
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