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ORIGINAL RESEARCH article
Front. Chem.
Sec. Medicinal and Pharmaceutical Chemistry
Volume 13 - 2025 | doi: 10.3389/fchem.2025.1509785
This article is part of the Research Topic Exploration of the Role of Heme Proteins in Biology with Experimental and Computational Methods View all 4 articles
Chronic Alcohol Intake Disrupts Cytochrome P450 Enzyme Activity in Alcoholic Fatty Liver Disease: Insights into Metabolic Alterations and Therapeutic Targets
Provisionally accepted- 1 Anhui Medical University, Hefei, China
- 2 First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China
Alcoholic fatty liver disease (AFLD) is a common consequence of chronic alcohol consumption, characterized by lipid accumulation and oxidative stress in the liver. Cytochrome P450 (CYP450) enzymes are essential in metabolizing alcohol and other compounds, but the specific long-term effects of alcohol on these enzymes remain unclear. This study examines how prolonged ethanol exposure influences CYP450 activity and expression in AFLD. Using a rat model, we identified significant alterations in key enzymes, such as CYP2E1, CYP2D6, and CYP3A1, associated with increased lipid accumulation and oxidative stress. Additionally, the expression of P-glycoprotein (P-gp) was elevated, suggesting that chronic alcohol intake may impact drug transport and excretion. These findings provide new insights into the molecular mechanisms of AFLD and emphasize the potential of CYP450 modulation as a therapeutic target. By highlighting how long-term ethanol exposure disrupts hepatic CYP450 enzyme profiles, this research lays the groundwork for developing personalized therapeutic strategies to improve outcomes for patients with AFLD.
Keywords: Alcoholic fatty liver, Chronic ethanol intake, cytochrome P450, rat model, Liver alcohol
Received: 11 Oct 2024; Accepted: 08 Jan 2025.
Copyright: © 2025 Zhu, Xie, Fang, Huang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qian Zhu, Anhui Medical University, Hefei, China
Jun Li, Anhui Medical University, Hefei, China
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