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REVIEW article
Front. Chem.
Sec. Chemical Biology
Volume 13 - 2025 | doi: 10.3389/fchem.2025.1492533
This article is part of the Research Topic Discovery and Function Research of Novel Natural Products View all 4 articles
Advances in the structural characterization and pharmacological activity of Salvia miltiorrhiza polysaccharides
Provisionally accepted
Yang Ke 1,2*
Yi jun Liu 2 Jia ning Zhang 2 Ya jing Chen 2
Jian Yang 1
Jun ping Xiao 3
Hanbin Lin 4* Hong jun Yang 1*- 1 China Academy of Chinese Medical Sciences, Beijing, Beijing Municipality, China
- 2 China Jiliang University, Hangzhou, China
- 3 Jiangxi Prozin Pharmaceutical, Jiangxi, China
- 4 Zhongshan Institute for Drug Discovery, SIMM CAS,, Guangdong, China
Background: Salvia miltiorrhiza Bunge is the dried root and rhizome of Salvia miltiorrhiza Bunge, a labiatae plant. Salvia miltiorrhiza polysaccharide (SMP) is the main active component of Salvia miltiorrhiza Bunge. The extraction methods of SMP mainly include water extraction, ultrasonic extraction, enzyme extraction, microwaveassisted extraction and acid-base extraction. It is mainly composed of glucose, arabinose, rhamnose, galactose and other monosaccharides. SMP has a variety of biological activities, including immune regulation, anti-tum, anti-oxidation, myocardial protection, liver protection and so on. Purpose：Salvia miltiorrhiza polysaccharide is widely used in nutraceuticals and pharmaceuticals, and has high research value. Natural polysaccharides are non-toxic, soluble in water, and have a wide range of biological activities, so they have broad research prospects. Methods：The data was collected using different online resources including PubMed, Google Scholar, and Web of Science using keywords given below. Results：In the past decades, various reports have shown that the pharmacological activities of Salvia miltiorrhiza polysaccharides have good effects, and the side effects are small. Conclusion: This paper summarizes the extraction and purification methods, molecular weight, monosaccharide composition, glycosidic linkage, pharmacological activity, toxicity, product development, clinical research and other contents of Salvia miltiorrhiza polysaccharides in recent years, providing a theoretical basis for further study of Salvia miltiorrhiza polysaccharides.
Keywords: Salvia miltiorrhiza polysaccharide, extraction, purification, Structural characteristics, Pharmacological activity
Received: 22 Oct 2024; Accepted: 25 Feb 2025.
Copyright: © 2025 Ke, Liu, Zhang, Chen, Yang, Xiao, Lin and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yang Ke, China Academy of Chinese Medical Sciences, Beijing, 100700, Beijing Municipality, China
Hanbin Lin, Zhongshan Institute for Drug Discovery, SIMM CAS,, Guangdong, China
Hong jun Yang, China Academy of Chinese Medical Sciences, Beijing, 100700, Beijing Municipality, China
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