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ORIGINAL RESEARCH article

Front. Chem.
Sec. Inorganic Chemistry
Volume 13 - 2025 | doi: 10.3389/fchem.2025.1491598
This article is part of the Research Topic Metallodrugs in Cancer Therapy View all 4 articles

Investigation of photophysical properties and potential biological applications of substituted Tris(polypyridyl)ruthenium(II) complexes

Provisionally accepted
Balamurali MM Balamurali MM 1*Sumitha Celin T Sumitha Celin T 2Allen Gnana Raj G Allen Gnana Raj G 2Prathima TS Prathima TS 3
  • 1 VIT University, Vellore, India
  • 2 Scott Christian College, Nagercoil, Tamil Nadu, India
  • 3 Vellore Institute of Technology (VIT), Chennai, Tamil Nadu, India

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    The photophysical properties of tris(polypyridyl)ruthenium(II) complex [Ru(dmbpy)3]2+ [dmbpy = 4,4′-dimethyl-2,2′-bipyridine] was investigated and compared with [Ru(bpy)3]2+ following both experimental and computational approaches. The variations in electronic properties of the complex in the ground and excited states were determined by density functional theory (DFT) methods and its impact on the anticancer, antioxidant and antimicrobial activities were also evaluated by molecular docking and dynamic simulation studies. Further evaluation on the potential of these complexes to serve as bioanalytes were investigated by their ability to bind with quinones, the well-known electron mediators in numerous light driven reactions. Following the above, the anticancer properties were evaluated against breast cancer related proteins. The obtained results revealed that the complex possess comparable anticancer and antioxidant potentials as that of [Ru(bpy)3]2+. The physical, electronic and biological properties of this complex depend on the nature of the ligands and the medium of investigation. Herein the potential applications of [Ru(bpy)3]2+ in clinical diagnostics as antioxidants and therapeutic agents were evaluated.

    Keywords: Tris(polypyridyl)ruthenium(II) complexes, Binding studies, anticancer, antioxidant, antimicrobial

    Received: 05 Sep 2024; Accepted: 03 Jan 2025.

    Copyright: © 2025 MM, T, G and TS. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Balamurali MM, VIT University, Vellore, India

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