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ORIGINAL RESEARCH article

Front. Chem.
Sec. Polymer Chemistry
Volume 12 - 2024 | doi: 10.3389/fchem.2024.1524096

Layer-by-Layer Assembled Film Can Serve as an Enhanced Reaction Environment for Diels-Alder Reaction

Provisionally accepted
Nanami Fujisawa Nanami Fujisawa Mitsuhiro Ebara Mitsuhiro Ebara *
  • National Institute for Materials Science, Tsukuba, Japan

The final, formatted version of the article will be published soon.

    Although the Diels-Alder reaction (DA) has garnered significant attention due to its numerous advantages, its long reaction time is a drawback. Herein, we investigated the effects of polarity difference on DA using Layer-by-Layer (LbL) films comprising polycationic polyallylamine hydrochloride and polyanionic poly(styrenesulfonic acid-co-furfuryl methacrylate) (poly(SS-co-FMA)) as the reaction environment. First, furan composition in poly(SS-co-FMA) was adjusted to be 19 mol% to achieve good water solubility and layer deposition. The successful formation of LbL films with 8 and 40 layers was confirmed by quartz crystal microbalance. The polarity within films and, consequently, the DA efficiency between furfuryl methacrylate and the maleimide in MAL-PEG2-NHS increased with an increasing number of layers up to 40 layers without requiring chemical modification on the reaction site of DA or any catalysts. Furthermore, we employed the LbL coating on the surface of magnetic nanoparticles (MNPs). The retro DA reaction (rDA) was successfully triggered by heating the MNPs by AC magnetic field. We believe that the proposed technology can serve as an enhanced DA reaction environment as well as temporal/spatial control of rDA in various applications.

    Keywords: Diels-Alder reaction, layer-by-layer, quartz crystal microbalance, magnetic nanoparticles, AC magnetic field

    Received: 07 Nov 2024; Accepted: 25 Nov 2024.

    Copyright: © 2024 Fujisawa and Ebara. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Mitsuhiro Ebara, National Institute for Materials Science, Tsukuba, Japan

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