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ORIGINAL RESEARCH article
Front. Chem.
Sec. Medicinal and Pharmaceutical Chemistry
Volume 12 - 2024 |
doi: 10.3389/fchem.2024.1515866
This article is part of the Research Topic Natural and Artificially-Engineered Medicines: Design, Characterization and Diseases Management View all 6 articles
Design, synthesis, in-vitro, in-vivo, and in-silico evaluation of novel substituted 1,3,4-thiadiazole derivatives as anticonvulsant agents
Provisionally accepted- 1 Department of Pharmacy, Banasthali Vidyapith, Banasthali, India
- 2 National Institute of Pharmaceutical Education and Research, Hyderabad, Andhra Pradesh, India
Ten novel 1,3,4-thiadiazole derivatives were synthesized, characterized and evaluated for in-vitro, in-vivo anticonvulsant activity and were found to have potent anticonvulsant action by inhibiting human carbonic anhydrase (CA) with no neurotoxicity observed.• Two compounds 6d and 7d displayed excellent anticonvulsant activity in MES and sc-PTZ seizure models with long-duration action at minimum dose and further evaluated for several biochemical parameter. • 6d compound was further docked against CA-II and CA-IX enzyme.
Keywords: 1, 3, 4-thiadiazoles, CA, Anticonvulsant activity, MES, sc-PTZ
Received: 23 Oct 2024; Accepted: 31 Dec 2024.
Copyright: © 2024 Anthwal, Pant, Preeti and Nain. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Dr. Sumitra Nain, Department of Pharmacy, Banasthali Vidyapith, Banasthali, India
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