Weiting Ma
Hongying Wang
*The final, formatted version of the article will be published soon.
ORIGINAL RESEARCH article
Front. Chem.
Sec. Molecular Liquids
Volume 12 - 2024 |
doi: 10.3389/fchem.2024.1508396
This article is part of the Research Topic Intermolecular Interaction Studies in Binary and Higher Order Liquid Mixtures, Ionic Liquids and Deep Eutectic Solvents (DES) Based Systems View all 3 articles
Synthesis, characterization and irritant effects of nonivamide irritant riot control agent based on ionic liquids
Provisionally accepted- State Key Laboratory of NBC Protection for Civilian, Beijing, China
Active Pharmaceutical Ingredients-Ionic liquids (API-ILs) can increase drug solubility and bioavailability of solid drugs without changing the structure of drug molecules. In the present work, nonivamide (pelargonic acid vanillylamide, PAVA) was used as the active drug and choline (Ch) and citric acid (CA) were selected as the ions to prepare PAVA-based ionic liquid ([Ch][PAVA] and [PAVA]3[CA]), respectively. The characterization and physical properties of [Ch][PAVA] and [PAVA]3[CA], such as FT-IR spectra, 1H NMR spectra, thermal stability and hydrophilicity, were investigated. And the irritant effects of the PAVA-based ionic liquids were measured by the animal irritation experiment. The results show that the PAVA-based ILs synthesized in this study may potentially serve as a promising novel riot control agent.
Keywords: Nonivamide, Riot control agent, Ionic Liquid, Solubility, irritant effects
Received: 09 Oct 2024; Accepted: 14 Nov 2024.
Copyright: © 2024 Ma, Wang, Wang, Chen, Yuan, Qin and Mei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hongying Wang, State Key Laboratory of NBC Protection for Civilian, Beijing, China
Zhenxiong Wang, State Key Laboratory of NBC Protection for Civilian, Beijing, China
Dong Chen, State Key Laboratory of NBC Protection for Civilian, Beijing, China
Ling Yuan, State Key Laboratory of NBC Protection for Civilian, Beijing, China
Liang Qin, State Key Laboratory of NBC Protection for Civilian, Beijing, China
Zongshu Mei, State Key Laboratory of NBC Protection for Civilian, Beijing, China
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