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ORIGINAL RESEARCH article

Front. Chem.
Sec. Medicinal and Pharmaceutical Chemistry
Volume 12 - 2024 | doi: 10.3389/fchem.2024.1507891
This article is part of the Research Topic Isolation, Structural Elucidation, and Biological Evaluation of Bioactive Products from Traditional Medicine-Volume II View all articles

Two previously undescribed triterpenoid saponins from the roots and rhizomes of Caulophyllum robustum Maxim

Provisionally accepted
Cong-Yu Zhang Cong-Yu Zhang 1Yu -Mei Wang Yu -Mei Wang 2Peng-cheng Qiu Peng-cheng Qiu 1Jia-Yu Feng Jia-Yu Feng 3Bing-Wen Wang Bing-Wen Wang 1Yu Cao Yu Cao 1Yi-Sha Wei Yi-Sha Wei 2Yi-Tong Zhou Yi-Tong Zhou 2Haifeng Tang Haifeng Tang 1*Yun-Yang Lu Yun-Yang Lu 1Qian Zhang Qian Zhang 1
  • 1 Air Force Medical University, Xi'an, China
  • 2 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China
  • 3 Xi'an Jiaotong University, Xi'an, China

The final, formatted version of the article will be published soon.

    Since ancient times, plants have provided humans with important bioactive compounds for the treatment of various diseases. Nine compounds were isolated from the roots and rhizomes of Caulophyllum robustum (a plant in the family Panaxaceae), including two new saponins C. Spanion A andC. Spanion B (1-2) andseven known saponins (3-9). The cytotoxicity of these compounds on human cancer cell lines was analyzed using MTT method. Compounds 6 and 9 exhibit cytotoxicity towards these three types of human cancer cells(＜10 μM). By utilizing the SEA platform for target prediction, a common tumor related target CD81 was identified. The molecular docking of saponins 1, 2, 6, and 9 with CD81 protein showed strong binding affinities ranging from -4.5 to -7.1 kcal/mol. Research has shown that these compounds can become potential anti-tumor drugs. Further research is still recommended to understand its exact molecular mechanism and toxicological effects.

    Keywords: Caulophyllum robustum Maxim, Triterpenoid saponin, structure identification, antitumor activity, molecular docking

    Received: 08 Oct 2024; Accepted: 11 Dec 2024.

    Copyright: © 2024 Zhang, Wang, Qiu, Feng, Wang, Cao, Wei, Zhou, Tang, Lu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Haifeng Tang, Air Force Medical University, Xi'an, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.