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ORIGINAL RESEARCH article

Front. Chem.
Sec. Medicinal and Pharmaceutical Chemistry
Volume 12 - 2024 | doi: 10.3389/fchem.2024.1489253
This article is part of the Research Topic Beyond Borders: Exploring Diverse Roles of Heterocyclic Compounds in Combatting Infections and Cancer View all 5 articles

Sustainable synthesis of silver nanoparticles from Azadirachta indica: Antimicrobial, antioxidant and in silico analysis for periodontal treatment

Provisionally accepted
Binapani Barik Binapani Barik 1*Bhabani S. Satapathy Bhabani S. Satapathy 2*Gurudutta Pattnaik Gurudutta Pattnaik 1*Desai V. Bhavrao Desai V. Bhavrao 3*Krishna P. Shetty Krishna P. Shetty 3*
  • 1 centurion university of technology and management, odisha, India, BHubaneswar, India
  • 2 GITAM School of Pharmacy, GITAM Deemed to be University, Hyderabad campus, Telangana, India, Hyderabad, India
  • 3 Department of Clinical Science, College of Dentistry, Ajman University, Centre of Medical and Bio-allied Health Science Research, , Al- Jruf,Ajman, P.O.Box 346,United Arab Emirates, Al- Jruf,Ajman, United Arab Emirates

The final, formatted version of the article will be published soon.

    This study explores using silver nanoparticles (AgNPs) to treat periodontal infection using Azadirachta indica leaf extract. The eco-friendly green synthesis process uses Azadirachta indica as a natural stabilizer and reducer, allowing AgNPs to be formed. Experimental AgNPs were characterized through transmission electron microscopy (TEM), Fouriertransform infrared spectroscopy (FTIR), Zeta potential, ultraviolet-visible spectroscopy (UV-Vis) etc. The antimicrobial, antioxidant potential of AgNPs was tested to identify its efficacy against periodontal infections. AgNPs were found spherical, nanosized 86nm. with positive surface -26.9 mV charge. TEM study depicted clear formation of discrete nanosize particles with smooth surface texture. Results showed strong antibacterial and anti-oxidant action of experimental AgNPs, preventing biofilm growth and bacterial viability. A higher binding affinity was observed between Quercetin and the selected protein, which is implicated in bacterial growth and biofilm formation on teeth. The study suggests that Azadirachta indica derived AgNPs could be a safe, efficacious, and eco-friendly alternative in place of conventional therapies to treat periodontal infection. Future in vivo studies are however warranted.

    Keywords: silver nanoparticles, Azadirachta indica, antimicrobial, antioxidant, molecular docking, admet

    Received: 31 Aug 2024; Accepted: 27 Sep 2024.

    Copyright: © 2024 Barik, Satapathy, Pattnaik, Bhavrao and Shetty. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Binapani Barik, centurion university of technology and management, odisha, India, BHubaneswar, India
    Bhabani S. Satapathy, GITAM School of Pharmacy, GITAM Deemed to be University, Hyderabad campus, Telangana, India, Hyderabad, India
    Gurudutta Pattnaik, centurion university of technology and management, odisha, India, BHubaneswar, India
    Desai V. Bhavrao, Department of Clinical Science, College of Dentistry, Ajman University, Centre of Medical and Bio-allied Health Science Research, , Al- Jruf,Ajman, P.O.Box 346,United Arab Emirates, Al- Jruf,Ajman, United Arab Emirates
    Krishna P. Shetty, Department of Clinical Science, College of Dentistry, Ajman University, Centre of Medical and Bio-allied Health Science Research, , Al- Jruf,Ajman, P.O.Box 346,United Arab Emirates, Al- Jruf,Ajman, United Arab Emirates

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