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ORIGINAL RESEARCH article
Front. Chem.
Sec. Nanoscience
Volume 12 - 2024 |
doi: 10.3389/fchem.2024.1478338
Magnetic gelatin-hesperidin microrobots promote proliferation and migration of dermal fibroblasts
Provisionally accepted- 1 The Fourth Hospital of Harbin Medical University, Harbin, China
- 2 Department of Obstetrics and Gynecology, Beijing, China
- 3 National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, China
- 4 State Key Laboratory of Common Mechanism Research for Major Diseases, Beijing, China
- 5 Peking Union Medical College Hospital, Beijing, China
- 6 Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
- 7 Harbin Medical University, Harbin, Heilongjiang, China
- 8 Zhengzhou University, Zhengzhou, Henan Province, China
- 9 Wanjia Compulsory Isolation and Drug Rehabilitation Hospital, Harbin, China
- 10 Harbin Institute of Technology, Harbin, Heilongjiang Province, China
- 11 State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, Heilongjiang Province, China
- 12 The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China
Dermal fibroblasts play a crucial role in the formation of granulation tissue in skin wounds. Consequently, the differentiation, migration, and proliferation of dermal fibroblasts are considered key factors in the skin wound healing process. However, in patients with diabetic foot ulcers, the proliferation and migration of fibroblasts are impaired by reactive oxygen species and inflammatory factors impair. Therefore, a novel magnetic gelatin-hesperidin microrobots drug delivery system was developed using microfluidics. The morphology, motility characteristics, and drug release of the microrobot were assessed, along with its impact on the proliferation and migration of human dermal fibroblasts under high-glucose conditions. Subjected to a rotating magnetic field, the microrobots exhibit precise, controllable, and flexible autonomous motion, achieving a maximum speed of 9.237 μm/s. In vitro drug release experiments revealed that approximately 78% of the drug was released within 30 minutes. It was demonstrated through cellular experiments that the proliferation of human dermal fibroblasts was actively promoted by the nanorobot, the migration ability of fibroblasts in a high-glucose state was enhanced, and good biocompatibility was exhibited. Hence, our study may
Keywords: Microrobots, gelatin-hesperidin, Fibroblasts, Diabetic foot ulcer, Wound Healing
Received: 09 Aug 2024; Accepted: 23 Sep 2024.
Copyright: © 2024 Sun, Yang, Zhang, Zhang, Liu, Wang, Song, Wang and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Han Zhang, Harbin Medical University, Harbin, 130012, Heilongjiang, China
Chunyu Liu, Wanjia Compulsory Isolation and Drug Rehabilitation Hospital, Harbin, China
Xiaoxiao Wang, Harbin Institute of Technology, Harbin, 150001, Heilongjiang Province, China
Wenping Song, State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, Heilongjiang Province, China
Lin Wang, State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, Heilongjiang Province, China
Qingsong Zhao, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China
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