Skip to main content

ORIGINAL RESEARCH article

Front. Chem.
Sec. Nanoscience
Volume 12 - 2024 | doi: 10.3389/fchem.2024.1478338

Magnetic gelatin-hesperidin microrobots promote proliferation and migration of dermal fibroblasts

Provisionally accepted
Xuyan Sun Xuyan Sun 1Hua Yang Hua Yang 2,3,4,5,6Han Zhang Han Zhang 7*Weiwei Zhang Weiwei Zhang 8Chunyu Liu Chunyu Liu 9*Xiaoxiao Wang Xiaoxiao Wang 10*Wenping Song Wenping Song 11*Lin Wang Lin Wang 11*Qingsong Zhao Qingsong Zhao 12*
  • 1 The Fourth Hospital of Harbin Medical University, Harbin, China
  • 2 Department of Obstetrics and Gynecology, Beijing, China
  • 3 National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, China
  • 4 State Key Laboratory of Common Mechanism Research for Major Diseases, Beijing, China
  • 5 Peking Union Medical College Hospital, Beijing, China
  • 6 Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
  • 7 Harbin Medical University, Harbin, Heilongjiang, China
  • 8 Zhengzhou University, Zhengzhou, Henan Province, China
  • 9 Wanjia Compulsory Isolation and Drug Rehabilitation Hospital, Harbin, China
  • 10 Harbin Institute of Technology, Harbin, Heilongjiang Province, China
  • 11 State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, Heilongjiang Province, China
  • 12 The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China

The final, formatted version of the article will be published soon.

    Dermal fibroblasts play a crucial role in the formation of granulation tissue in skin wounds. Consequently, the differentiation, migration, and proliferation of dermal fibroblasts are considered key factors in the skin wound healing process. However, in patients with diabetic foot ulcers, the proliferation and migration of fibroblasts are impaired by reactive oxygen species and inflammatory factors impair. Therefore, a novel magnetic gelatin-hesperidin microrobots drug delivery system was developed using microfluidics. The morphology, motility characteristics, and drug release of the microrobot were assessed, along with its impact on the proliferation and migration of human dermal fibroblasts under high-glucose conditions. Subjected to a rotating magnetic field, the microrobots exhibit precise, controllable, and flexible autonomous motion, achieving a maximum speed of 9.237 μm/s. In vitro drug release experiments revealed that approximately 78% of the drug was released within 30 minutes. It was demonstrated through cellular experiments that the proliferation of human dermal fibroblasts was actively promoted by the nanorobot, the migration ability of fibroblasts in a high-glucose state was enhanced, and good biocompatibility was exhibited. Hence, our study may

    Keywords: Microrobots, gelatin-hesperidin, Fibroblasts, Diabetic foot ulcer, Wound Healing

    Received: 09 Aug 2024; Accepted: 23 Sep 2024.

    Copyright: © 2024 Sun, Yang, Zhang, Zhang, Liu, Wang, Song, Wang and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Han Zhang, Harbin Medical University, Harbin, 130012, Heilongjiang, China
    Chunyu Liu, Wanjia Compulsory Isolation and Drug Rehabilitation Hospital, Harbin, China
    Xiaoxiao Wang, Harbin Institute of Technology, Harbin, 150001, Heilongjiang Province, China
    Wenping Song, State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, Heilongjiang Province, China
    Lin Wang, State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, Heilongjiang Province, China
    Qingsong Zhao, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.