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ORIGINAL RESEARCH article

Front. Chem.
Sec. Nanoscience
Volume 12 - 2024 | doi: 10.3389/fchem.2024.1478021
This article is part of the Research Topic Advanced Biomimetic Composites toward Customized Biomedical Application View all articles

Ultrasensitive and highly selective Co 2+ detection based on the chiral optical activities of L-glutathione-modified gold nanoclusters

Provisionally accepted
Qi Ding Qi Ding Fang Wang Fang Wang Weimin Yang Weimin Yang Xinhe Xing Xinhe Xing Hengwei Lin Hengwei Lin Liguang Xu Liguang Xu Si Li Si Li *
  • Jiangnan University, Wuxi, China

The final, formatted version of the article will be published soon.

    Developing highly sensitive and selective detection methods is crucial for environmental and healthcare monitoring. In this study, the chiral and fluorescent signals of L-glutathione-modified gold nanoclusters (L-GSH-Au NCs) were discovered to be responsive to Co 2+ , which displayed linear correlations with the concentration changes of Co 2+ . Notably, the chiral signal was more sensitive than the FL signal, whose limit of detection (LOD) was calculated to be 0.37 μM and 3.93 times lower than the LOD obtained with fluorescent signals. Moreover, the chiral signals exhibited unexpectedly high selectivity towards Co 2+ , effectively avoiding interference from other metal ions and biomolecules. Furthermore, the concentrations of Co 2+ in various samples, such as Taihu water, tap water, bottled water, and animal serum, were accurately quantified using the chiral signals of L-GSH-Au NCs without complex pretreatment, with recoveries ranging between 95.64% and 103.22%. This study not only provides an innovative approach for Co 2+ detection but also highlights the detection capabilities of chiral signals in complex environments.

    Keywords: Chirality, fluorescence, nanoclusters, Cobalt ion, detection

    Received: 09 Aug 2024; Accepted: 23 Sep 2024.

    Copyright: © 2024 Ding, Wang, Yang, Xing, Lin, Xu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Si Li, Jiangnan University, Wuxi, China

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