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REVIEW article

Front. Chem.
Sec. Organic Chemistry
Volume 12 - 2024 | doi: 10.3389/fchem.2024.1477764

Yamaguchi Esterification: A Key Step Toward The Synthesis of Natural Products And Their Analogues: A Review

Provisionally accepted
Ramsha Munir Ramsha Munir 1Ameer Fawad Zahoor Ameer Fawad Zahoor 1*Muhammad Naveed Anjum Muhammad Naveed Anjum 1Asim Mansha Asim Mansha 1Dr. Ali Irfan Dr. Ali Irfan 1Aijaz Rasool Chaudhry Aijaz Rasool Chaudhry 2Ahmad Irfan Ahmad Irfan 3Katarzyna Kotwica-Mojzych Katarzyna Kotwica-Mojzych 4Mariola Głowacka Mariola Głowacka 5Mariusz Mojzych Mariusz Mojzych 5*
  • 1 Government College University, Faisalabad, Faisalabad, Punjab, Pakistan
  • 2 University of Bisha, BISHA, Saudi Arabia
  • 3 King Khalid University, Abha, Saudi Arabia
  • 4 Medical University of Lublin, Lublin, Lublin, Poland
  • 5 The Mazovian Academy in Plock, Plock, Masovian Voivodeship, Poland

The final, formatted version of the article will be published soon.

    The Yamaguchi reagent, based on 2,4,6-trichlorobenzoyl chloride (TCBC) and 4-dimethylaminopyridine (DMAP), is an efficient tool for the intermolecular (esterification) reaction between an acid and an alcohol in the presence of suitable base (Et3N or iPr2NEt) and solvent (THF, DCM or toluene). The Yamaguchi protocol is renowned for its ability to efficiently produce a diverse array of functionalized esters, promoting high yields, regioselectivity and easy handling under mild conditions with short reaction times. Herein, the recent utilization of Yamaguchi reagent has been reviewed in the synthesis of various natural products such as macrolides, terpenoids, polyketides, peptides and metabolites etc.

    Keywords: Yamaguchi esterification, Macrolides, terpenoids, Polyketides, Peptides, Metabolites

    Received: 08 Aug 2024; Accepted: 09 Sep 2024.

    Copyright: © 2024 Munir, Zahoor, Anjum, Mansha, Irfan, Chaudhry, Irfan, Kotwica-Mojzych, Głowacka and Mojzych. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Ameer Fawad Zahoor, Government College University, Faisalabad, Faisalabad, 38000, Punjab, Pakistan
    Mariusz Mojzych, The Mazovian Academy in Plock, Plock, Masovian Voivodeship, Poland

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.