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ORIGINAL RESEARCH article
Front. Chem.
Sec. Nanoscience
Volume 12 - 2024 |
doi: 10.3389/fchem.2024.1477724
This article is part of the Research Topic Bioactive Containing Plant Based Waste for (Nano)-Biocomposites: Applications in Biomedicine, Health, and Bioremediation View all 4 articles
Activated Carbon-Coated Iron Oxide Magnetic Nanocomposite (IONPs@CtAC) Loaded with Morin hydrate for Drug-Delivery Applications
Provisionally accepted
Yusuf Doğan
1*
Cem Öziç
2*
Erdal Ertaş
3
Ayşe Baran
1
Gvozden Rosic
4*
Dragica Selakovic
4
Aziz Eftekhari
5*- 1 Mardin Artuklu University, Mardin, Mardin, Türkiye
- 2 Kafkas University, Kars, Kars, Türkiye
- 3 Batman University, Batman, Batman, Türkiye
- 4 University of Kragujevac, Kragujevac, Serbia
- 5 Ege University, Bornova, İzmir, Türkiye
Cancer is a major disease that affects millions of people around the world every year. This disease affects individuals of all ages, races and backgrounds. Since drugs used to treat cancer cannot distinguish between cancerous and healthy cells, they cause systemic toxicity along with serious side effects. Recently, controlled drug release systems have been developed to reduce the side effects caused by anti-cancer drugs used for treatment. Morin is an anticancer drug with a flavonol structure that has been extensively researched for its antioxidant, anti-inflammatory, antitumoral and antibacterial properties, especially found in Chinese herbs and fruits, as well as its multiple positive effects on different diseases. In this study, biocompatible activated carbon obtained using the fruits of the Celtis tournefortii plant was coated on the surface of iron oxide magnetic nanoparticles and a nanocomposite with magnetic properties was synthesized. Characterization of the synthesized activated carbon-coated iron oxide magnetic nanocomposite was confirmed by Fourier Transform Infrared, Scanning Electron Microscopy, Energy Dispersive Xray Spectrometry, X-Ray Diffraction, dynamic light scattering , Zeta Potential and vibrating sample magnetometer. The cytotoxic effects of the drug-loaded magnetic nanocomposite were examined in HT-29 (Colorectal), T98-G (Gliablastoma) cancer cell lines and Human Umbilical Vein Endothelial Cells (HUVEC) healthy cell line. The Morin loading and release behavior of activated carbon-coated iron oxide magnetic nanocomposite was studied, and the results showed that up to 60% of the adsorbed morin was released within 4 hours. In summary, activated carbon-coated iron oxide magnetic nanocomposite carriers have shown promising results for the delivery of morin drug.
Keywords: Anticancer activity, IONPs@CtAC Magnetic Nanocomposite, Morin hydrate, Nano drug delivery system, Celtis tournefortii activated carbon
Received: 08 Aug 2024; Accepted: 30 Sep 2024.
Copyright: © 2024 Doğan, Öziç, Ertaş, Baran, Rosic, Selakovic and Eftekhari. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yusuf Doğan, Mardin Artuklu University, Mardin, Mardin, Türkiye
Cem Öziç, Kafkas University, Kars, 36100, Kars, Türkiye
Gvozden Rosic, University of Kragujevac, Kragujevac, 34000, Serbia
Aziz Eftekhari, Ege University, Bornova, 35040, İzmir, Türkiye
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