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ORIGINAL RESEARCH article

Front. Chem.
Sec. Chemical Biology
Volume 12 - 2024 | doi: 10.3389/fchem.2024.1471148

Synthesis and Characterization of silk fibroin-MXene Composite Electrospun Fibers for Biomedical Applications

Provisionally accepted
Chengzhi Liang Chengzhi Liang 1*Yuan Cao Yuan Cao 2Zaiwei Fan Zaiwei Fan 1Jiawei Kang Jiawei Kang 1Yudan Zhu Yudan Zhu 1Jun Tao Jun Tao 1*
  • 1 Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China
  • 2 People’s Hospital of Rizhao, Rizhao, China

The final, formatted version of the article will be published soon.

    Two-dimensional (2D) MXene, known for its excellent physical and chemical properties, has emerged as a promising material in the biomedical field. In this study, we synthesized SF-MXene composite electrospun fibers and assessed their potential applications in biomedicine. Field emission scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, mechanical testing machine, thermogravimetry, and contact angle were used to analyze the composite fibers. In addition, the protein adsorption capacity and possible biomineralizing activity capacity of the composite fibers were also determined. Fibroblasts (L929) and preosteoblasts (MC3T3-E1) were used as models to evaluate the biocompatibility of the composite fibers and the effect of the composite fibers on ALP activity of MC3T3-E1. The results showed that the two cell lines showed high cell activity on the SF-MXene composite electrospun fiber. Taking these findings into account, MXene-based composites can potentially be used in biomedical applications in an expanded capacity.

    Keywords: silk fibroin, MXene, Electrospun, Biocompatibility, biomedical applications

    Received: 26 Jul 2024; Accepted: 03 Dec 2024.

    Copyright: © 2024 Liang, Cao, Fan, Kang, Zhu and Tao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Chengzhi Liang, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, China
    Jun Tao, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.