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MINI REVIEW article

Front. Chem.
Sec. Organic Chemistry
Volume 12 - 2024 | doi: 10.3389/fchem.2024.1470629
This article is part of the Research Topic Synthesis, Structural Analysis, and Conformational Behavior of BODIPY Dyes and Their Congeners View all articles

Near-Infrared fluorescent BODIPYs: Green-Synthesis, photophysical properties, and their applications in biomedical molecular imaging

Provisionally accepted
Raul Segovia Pérez Raul Segovia Pérez Marisol Ibarra Rodrı́guez Marisol Ibarra Rodrı́guez Blanca M. Muñoz Flores Blanca M. Muñoz Flores Víctor Jiménez Pérez Víctor Jiménez Pérez *
  • Autonomous University of Nuevo León, San Nicolás de los Garza, Mexico

The final, formatted version of the article will be published soon.

    Available data on BODIPYs with near-infrared (NIR) fluorescent properties were reviewed. BODIPYs are used as fluorescent dyes can be employed in various fields due to their facile modification and potential for obtaining high quantum yields. The first section of this mini-review is focused on sustainable synthesis methods, for example, mechanosynthesis, microwave-assisted synthesis and multicomponent reactions, and the photophysical properties of BODIPYs. The second section explores their application in biomedical molecular imaging as markers, sensors, and therapeutic agents, since these compounds exhibit near-infrared fluorescence, allowing deeper tissue penetration and reduced autofluorescence. Recent advances in sustainable synthesis and development of NIR-emitting BODIPYs are promising for future advances in medical diagnosis and treatment.

    Keywords: BODIPY, near-infrared, Green synthesis, Mechanosynthesis, Microwave-assisted synthesis, multicomponent reaction, Fluorescent bioimaging, in vitro

    Received: 25 Jul 2024; Accepted: 15 Aug 2024.

    Copyright: © 2024 Segovia Pérez, Ibarra Rodrı́guez, Muñoz Flores and Jiménez Pérez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Víctor Jiménez Pérez, Autonomous University of Nuevo León, San Nicolás de los Garza, Mexico

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