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ORIGINAL RESEARCH article

Front. Chem.
Sec. Nanoscience
Volume 12 - 2024 | doi: 10.3389/fchem.2024.1469568
This article is part of the Research Topic Chemiluminescence and Nanomaterials View all articles

In vivo self-assembled albumin nanoparticle elicit antitumor immunity of PD-1 inhibitor by imaging and clearing tumor-associated macrophages

Provisionally accepted
Cheng Yu Cheng Yu 1Linan Hu Linan Hu 2*Qilin Yu Qilin Yu 1*Yulu Ren Yulu Ren 1*Minping Zhang Minping Zhang 1*Lujing Gao Lujing Gao 1*Shiyi Lyu Shiyi Lyu 1Junli Wang Junli Wang 3*Enhua Xiao Enhua Xiao 1*Zhu Chen Zhu Chen 1*Quanliang Shang Quanliang Shang 1*Pengfei Xu Pengfei Xu 4*
  • 1 Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, China
  • 2 Department of Radiology, Zhuzhou Central Hospital, Zhuzhou, Hunan, China, Zhuzhou, China
  • 3 Department of Ultrasound, The Air Force Hospital of Southern Theater Command, Guangzhou, Guangdong, China, Guangzhou, China
  • 4 Department of Nuclear Medicine, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong Province, Weifang, China

The final, formatted version of the article will be published soon.

    Eliciting anti-tumor immune responses and improving the tumor microenvironment crucial for boosting the effectiveness of anti-PD-1 immunotherapy. Tumor-associated macrophages (TAMs), the primary types of immune cells infiltrating tumors, play a critical role in the formation of an immunosuppressive microenvironment. In this study, we constructed a novel Evans Blue (EB)-based in vivo self-assembled nanocarrier system, mUNO-EB-ICG-Fc@Alb nanoparticles (designated as MA NPs), for targeted imaging and clearance of M2-TAMs to elicit antitumor immunotherapy of PD-1 inhibitor. In vitro experiments demonstrated the specific fluorescence imaging and killing effect of MA NPs on M2-TAMs. In vivo experiments shown that MA NPs-induced chemodynamic therapy (CDT) successfully reversed the tumor immunosuppressive microenvironment (ITM), promoted intratumoral infiltration of T lymphocytes, and ultimately enhancing the anti-tumor immunotherapy effect of PD-1 inhibitors. This study might provide good inspiration for improving the therapeutic efficacy of cancer immunotherapy.

    Keywords: Albumin nanoparticle, tumor-associated macrophage, NIR-II imaging, CDT, Immunotherapy

    Received: 24 Jul 2024; Accepted: 23 Sep 2024.

    Copyright: © 2024 Yu, Hu, Yu, Ren, Zhang, Gao, Lyu, Wang, Xiao, Chen, Shang and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Linan Hu, Department of Radiology, Zhuzhou Central Hospital, Zhuzhou, Hunan, China, Zhuzhou, China
    Qilin Yu, Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, China
    Yulu Ren, Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, China
    Minping Zhang, Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, China
    Lujing Gao, Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, China
    Junli Wang, Department of Ultrasound, The Air Force Hospital of Southern Theater Command, Guangzhou, Guangdong, China, Guangzhou, China
    Enhua Xiao, Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, China
    Zhu Chen, Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, China
    Quanliang Shang, Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, China
    Pengfei Xu, Department of Nuclear Medicine, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong Province, Weifang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.