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ORIGINAL RESEARCH article
Front. Chem.
Sec. Nanoscience
Volume 12 - 2024 |
doi: 10.3389/fchem.2024.1469568
In vivo self-assembled albumin nanoparticle elicit antitumor immunity of PD-1 inhibitor by imaging and clearing tumor-associated macrophages
Provisionally accepted- 1 Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, China
- 2 Department of Radiology, Zhuzhou Central Hospital, Zhuzhou, Hunan, China, Zhuzhou, China
- 3 Department of Ultrasound, The Air Force Hospital of Southern Theater Command, Guangzhou, Guangdong, China, Guangzhou, China
- 4 Department of Nuclear Medicine, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong Province, Weifang, China
Eliciting anti-tumor immune responses and improving the tumor microenvironment crucial for boosting the effectiveness of anti-PD-1 immunotherapy. Tumor-associated macrophages (TAMs), the primary types of immune cells infiltrating tumors, play a critical role in the formation of an immunosuppressive microenvironment. In this study, we constructed a novel Evans Blue (EB)-based in vivo self-assembled nanocarrier system, mUNO-EB-ICG-Fc@Alb nanoparticles (designated as MA NPs), for targeted imaging and clearance of M2-TAMs to elicit antitumor immunotherapy of PD-1 inhibitor. In vitro experiments demonstrated the specific fluorescence imaging and killing effect of MA NPs on M2-TAMs. In vivo experiments shown that MA NPs-induced chemodynamic therapy (CDT) successfully reversed the tumor immunosuppressive microenvironment (ITM), promoted intratumoral infiltration of T lymphocytes, and ultimately enhancing the anti-tumor immunotherapy effect of PD-1 inhibitors. This study might provide good inspiration for improving the therapeutic efficacy of cancer immunotherapy.
Keywords: Albumin nanoparticle, tumor-associated macrophage, NIR-II imaging, CDT, Immunotherapy
Received: 24 Jul 2024; Accepted: 23 Sep 2024.
Copyright: © 2024 Yu, Hu, Yu, Ren, Zhang, Gao, Lyu, Wang, Xiao, Chen, Shang and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Linan Hu, Department of Radiology, Zhuzhou Central Hospital, Zhuzhou, Hunan, China, Zhuzhou, China
Qilin Yu, Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, China
Yulu Ren, Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, China
Minping Zhang, Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, China
Lujing Gao, Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, China
Junli Wang, Department of Ultrasound, The Air Force Hospital of Southern Theater Command, Guangzhou, Guangdong, China, Guangzhou, China
Enhua Xiao, Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, China
Zhu Chen, Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, China
Quanliang Shang, Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, China
Pengfei Xu, Department of Nuclear Medicine, Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong Province, Weifang, China
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