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ORIGINAL RESEARCH article

Front. Chem.
Sec. Analytical Chemistry
Volume 12 - 2024 | doi: 10.3389/fchem.2024.1463273
This article is part of the Research Topic Challenges in Spectroscopic Probe Design for Bioanalysis View all articles

Challenges in "Probing Spectroscopic Probes" for Non-Invasive Simultaneous Disease Diagnosis

Provisionally accepted
Samir Kumar Pal Samir Kumar Pal 1*Lopamudra Roy Lopamudra Roy 2Shweta Paul Shweta Paul 3Amrita Banerjee Amrita Banerjee 4Ria Ghosh Ria Ghosh 1Susmita Mondal Susmita Mondal 1Monojit Das Monojit Das 5Nivedita Pan Nivedita Pan 1Ishitri Das Ishitri Das 3Soumendra Singh Soumendra Singh 1Debasish Bhattacharya Debasish Bhattacharya 3Asim Kumar Mallick Asim Kumar Mallick 3
  • 1 S.N. Bose National Centre for Basic Sciences, Calcutta, India
  • 2 University of Calcutta, Kolkata, West Bengal, India
  • 3 Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, India
  • 4 Jadavpur University, Kolkata, West Bengal, India
  • 5 Vidyasagar University, Midnapore, West Bengal, India

The final, formatted version of the article will be published soon.

    Non-invasive diagnosis of human diseases relies on the detection of molecular marker (probe) in a painless manner. Although the molecular markers often used are extrinsic and intrinsic, the intrinsic disease probes (molecular markers) are preferable given the fact that the probes are omnipresent in our body and deviation of their concentration from normal limit clearly indicates anomaly in human bodies i.e. disease. Here, we report non-invasive spectroscopic measurements of total hemoglobin, bilirubin, and the ratio of oxy and deoxy hemoglobin as disease markers of anemia, jaundice, and oxygen deficiency respectively using a meticulously designed optical fiber probe. The challenges in our continuous effort associated with the designing of the fiber probe for the simultaneous non-invasive detection including optical power, spectral density of the probing light and resolution of the spectrometer were found to be critical in the measurement. Finally, a fiber-less, extremely portable and low-cost prototype is developed and performed human clinical trial for the diagnosis of the diseases and compared with the conventional techniques (blood test).

    Keywords: non-invasive, haemoglobin, Bilirubin, oxygen saturation, Portable, low cost

    Received: 11 Jul 2024; Accepted: 29 Nov 2024.

    Copyright: © 2024 Pal, Roy, Paul, Banerjee, Ghosh, Mondal, Das, Pan, Das, Singh, Bhattacharya and Kumar Mallick. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Samir Kumar Pal, S.N. Bose National Centre for Basic Sciences, Calcutta, India

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.