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MINI REVIEW article
Front. Chem.
Sec. Analytical Chemistry
Volume 12 - 2024 |
doi: 10.3389/fchem.2024.1447312
Recent research progress in tetrodotoxin detection and quantitative analysis methods
Provisionally accepted
Chao Lin
1
Qirong Li
2
Dong Liu
1
Qiang Feng
2
Hengzong Zhou
2
Bohe Shi
2
Xinxin Zhang
2
Yurui Hu
2
Xinmiao Jiang
2
Xiaoming Sun
1
Dongxu Wang
2*- 1 School of Grain Science and Technology, Jilin Business and Technology College, Changchun, Hebei Province, China
- 2 Laboratory Animal Center, College of Animal Science, Jilin University, Changchun, Hebei Province, China
Tetrodotoxin (TTX) is a highly potent and widely distributed ion-channel marine neurotoxin; it has no specific antidote and poses a great risk to human health. Therefore, detecting and quantifying TTX to effectively implement prevention strategies is important for food safety. The development of novel and highly sensitive, highly specific, rapid, and simple techniques for trace TTX detection has attracted widespread attention. This review summarizes the latest advances in the detection and quantitative analysis of TTX, covering detection methods based on biological and cellular sensors, immunoassays and immunosensors, aptamers, and liquid chromatography-mass spectrometry. It further discusses the advantages and applications of various detection technologies developed for TTX and focuses on the frontier areas and development directions of TTX detection, providing relevant information for further investigations.
Keywords: Tetrodotoxin, Detection methods, immunosensors, aptamer, LC-MS
Received: 13 Jun 2024; Accepted: 29 Jul 2024.
Copyright: © 2024 Lin, Li, Liu, Feng, Zhou, Shi, Zhang, Hu, Jiang, Sun and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Dongxu Wang, Laboratory Animal Center, College of Animal Science, Jilin University, Changchun, Hebei Province, China
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