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MINI REVIEW article

Front. Chem.
Sec. Chemical Biology
Volume 12 - 2024 | doi: 10.3389/fchem.2024.1444801
This article is part of the Research Topic Reviews in Chemistry View all 8 articles

The application of nanodiscs in membrane protein drug discovery & development and drug delivery

Provisionally accepted
Yingkui Dong Yingkui Dong 1,2,3Huan Tang Huan Tang 2*Han Dai Han Dai 1*Hongxin Zhao Hongxin Zhao 1,2*Junfeng Wang Junfeng Wang 1,3,4*
  • 1 High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences (CAS), Hefei, Anhui Province, China
  • 2 Independent researcher, Hefei, China
  • 3 Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui Province, China
  • 4 University of Science and Technology of China, Hefei, Anhui Province, China

The final, formatted version of the article will be published soon.

    The phospholipid bilayer nanodiscs (LNDs), as a rapidly-developing tool in recent years, provide a natural bio-memebrane environment to maintain the native conformation and functions of membrane proteins as well as a versatile delivery vehicle for a variety of hydrophobic and hydrophilic drugs. We have seen unprecedented advantages of phospholipid bilayer nanodiscs in membrane protein structure characterization, biochemical and physiological studies of membrane proteins, membrane environment studies, drug discovery & development, and drug delivery. Many previous reviews have been mainly focused on the advantages of nanodiscs in membrane protein researches, but few have touched upon the importance and potential application of nanodiscs in pharmaceutical industries. This review will provide general description of the structural characteristics, advantages, classification, and applications of phospholipid nanodiscs, with particular focus on nanodisc-enabled membrane protein drug discovery & development as well as drug delivery.

    Keywords: nanodisc (ND), membrane protein, Drug discovery & development, Drug Delievery, Membrane scaffold protein (MSP)

    Received: 06 Jun 2024; Accepted: 02 Sep 2024.

    Copyright: © 2024 Dong, Tang, Dai, Zhao and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Huan Tang, Independent researcher, Hefei, China
    Han Dai, High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences (CAS), Hefei, 230031, Anhui Province, China
    Hongxin Zhao, High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences (CAS), Hefei, 230031, Anhui Province, China
    Junfeng Wang, Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, Anhui Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.