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ORIGINAL RESEARCH article

Front. Chem.
Sec. Analytical Chemistry
Volume 12 - 2024 | doi: 10.3389/fchem.2024.1438321

Digital identification and adulteration analysis of Codonopsis Radix and Stellariae Radix based on the "digital identity" of chemical compositions

Provisionally accepted
Xianrui Wang Xianrui Wang *Jiating Zhang Jiating Zhang Wen-guang Jing Wen-guang Jing Xiaohan Guo Xiaohan Guo Minghua Li Minghua Li Xianlong Cheng Xianlong Cheng Feng Wei Feng Wei
  • National Institutes for Food and Drug Control (China), Beijing, China

The final, formatted version of the article will be published soon.

    Under the background of digitalization of traditional Chinese medicine (TCM), to realize the digital identification and adulteration analysis of Codonopsis Radix (CR) and Stellariae Radix (SR) based on the chemical analysis. This study combined digitalization concepts and chemical analysis and conducted chemical analysis on CR and SR from different batches based on UHPLC-QTOF-MS E .Further, the shared ions were extracted from different batches of CR and SR as their "ions characterization" respectively after digital quantization. Then, the data matrices of unique ions of CR relative to SR and SR relative to CR were screened out, and the Top-N ions were outputted as the "digital identities" of CR and SR, sorted by ionic strength. Finally, the above "digital identities" of CR and SR were used as benchmarks for matching positive samples and market samples to give feedback on the matching credibility (MC) for identification and adulteration analysis. The results showed that based on the "digital identities" of CR and SR, the digital identification of CR, SR, and positive samples can be realized at the individual level of TCM efficiently and accurately, even if 3 % of SR in the mixed samples can still be identified efficiently and accurately. Moreover, one of the 12 batches of market samples was identified as an adulterated sample. It proved that the identification and adulteration analysis of two herbs can be realized efficiently and quickly through the "digital identities" of chemical compositions. It has important reference significance for developing digital identification of CR and SR at the individual level of Chinese medicine based on the "digital identity" of chemical compositions, which was beneficial to the construction of digital quality control of CR and SR.

    Keywords: Adulteration analysis, digital identification, Codonopsis Radix, Stellariae Radix, "digital identity", chemical analysis

    Received: 25 May 2024; Accepted: 18 Oct 2024.

    Copyright: © 2024 Wang, Zhang, Jing, Guo, Li, Cheng and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xianrui Wang, National Institutes for Food and Drug Control (China), Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.