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ORIGINAL RESEARCH article

Front. Chem.
Sec. Organic Chemistry
Volume 12 - 2024 | doi: 10.3389/fchem.2024.1425953
This article is part of the Research Topic Actinomycete Natural Products: Isolation, Structure Elucidation, Biological Activity, Biosynthesis, and Yield Improvement View all 5 articles

Novel metabolite madeirone and neomarinone extracted from Streptomyces aculeoletus as marine antibiofilm and antifouling agents

Provisionally accepted
Julian L. Wissner Julian L. Wissner 1,2,3Joana Almeida Joana Almeida 4Inês R. Grilo Inês R. Grilo 1,2Jhenifer F. Oliveira Jhenifer F. Oliveira 1,2Carolina Brízida Carolina Brízida 1,2Wendy Escobedo-Hinojosa Wendy Escobedo-Hinojosa 1,2,3Isabel Cunha Isabel Cunha 4Rita G. Sobral Rita G. Sobral 1,2Vitor Vasconcelos Vitor Vasconcelos 4,5Susana P. Gaudêncio Susana P. Gaudêncio 1,2*
  • 1 Applied Biomolecular Sciences Unit, Faculty of Science and Technology, New University of Lisbon, Caparica, Portugal
  • 2 Associate Laboratory i4HB - Institute for Health and Bioeconomy, University of Lisbon, Lisbon, Lisbon, Portugal
  • 3 Unidad de Química en Sisal, Facultad de Química, Universidad Nacional Autónoma de México,, Sisal, Mexico
  • 4 Interdisciplinary Center for Marine and Environmental Research, University of Porto, Matosinhos, Porto, Portugal
  • 5 University of Porto, Porto, Portugal

The final, formatted version of the article will be published soon.

    Biofouling presents a significant economic threat to various marine industries, resulting in substantial financial losses that can amount to billions of euros annually. This study addresses the pressing need for effective alternatives to traditional antifouling agents, especially in the aftermath of the global prohibition of organotin compounds.Our research highlights the importance of madeirone (1), a novel marinone derivative discovered in the framework of this study, and neomarinone (2), both isolated from Streptomyces aculeolatus PTM-346, as potent inhibitors of both micro and macrofouling marine species. Madeirone (1) displayed significant antibiofilm efficacy inhibition against Phaeobacter inhibens (up to 66%),

    Keywords: Blue biotechnology, Marine Natural Products, actinomycetes bioprospection, Meroterpenoids, Hybrid isoprenoids, marine biofilm and biofouling, antifouling. eco-friendly paints and coatings

    Received: 30 Apr 2024; Accepted: 27 Jun 2024.

    Copyright: © 2024 Wissner, Almeida, Grilo, Oliveira, Brízida, Escobedo-Hinojosa, Cunha, Sobral, Vasconcelos and Gaudêncio. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Susana P. Gaudêncio, Applied Biomolecular Sciences Unit, Faculty of Science and Technology, New University of Lisbon, Caparica, 2829-516, Portugal

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.