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REVIEW article

Front. Chem.
Sec. Analytical Chemistry
Volume 12 - 2024 | doi: 10.3389/fchem.2024.1425774
This article is part of the Research Topic Highly Efficient Selections and Applicable Utilizations of Aptamers as Molecular Recognition Elements View all articles

Screening Biotoxin Aptamer and Their Application of Optical Aptasensor in Food Stuff: A Review

Provisionally accepted
Jiefang Sun Jiefang Sun 1*Meng Zhang Meng Zhang 1Qianlong Gao Qianlong Gao 2Bing Shao Bing Shao 1*
  • 1 Beijing Center for Disease Prevention and Control (Beijing CDC), Beijing, China
  • 2 Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan Province, China

The final, formatted version of the article will be published soon.

    Biotoxins are ranges of toxic substances produced by animals, plants and microorganisms, which could contaminate foods during their production, processing, transportation or storage, thus leading to foodborne illness, even food terrorism.Therefore, proposing simple, rapid and effective detection methods for ensuring food free from biotoxin contaminate show highly realistic demand. Aptamers are singlestranded oligonucleotide obtained from the systematic evolution of ligands by exponential enrichment (SELEX). They can specifically bind to wide ranges of targets with high affinity, thus have become attractive recognizing units in safety monitoring in food control and anti-terrorism. In this paper, we reviewed the technical points and difficulties of typical aptamer screening processes for biotoxin. For promoting understanding of food control in the food supply chain, the latest progresses in rapid optical detection of biotoxin based on aptamer was summarized. In the end, we outlined some challenges and perspects in this field. We hope this paper could stimulate wide interests in developing advanced sensing systems for ensuring food safety.

    Keywords: Biotoxins, aptamers, Food Safety, Optical, Biosensors

    Received: 30 Apr 2024; Accepted: 28 Jun 2024.

    Copyright: © 2024 Sun, Zhang, Gao and Shao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jiefang Sun, Beijing Center for Disease Prevention and Control (Beijing CDC), Beijing, China
    Bing Shao, Beijing Center for Disease Prevention and Control (Beijing CDC), Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.