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ORIGINAL RESEARCH article

Front. Chem.
Sec. Nanoscience
Volume 12 - 2024 | doi: 10.3389/fchem.2024.1413077
This article is part of the Research Topic Recent Advances in Pharmaceutical Nanobiotechnology of Natural Products View all articles

Effect of precipitating agent, N2 gas, extract volume and pH on the magnetic properties of magnetite nanoparticles by green synthesis from aqueous pomegranate peel extract

Provisionally accepted
Marzieh Dehghani Marzieh Dehghani Behnam Hajipour-Verdom Behnam Hajipour-Verdom Parviz Abdolmaleki Parviz Abdolmaleki *
  • Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran

The final, formatted version of the article will be published soon.

    Superparamagnetic nanoparticles (SPMNPs) have attracted considerable attention in biomedicine, particularly magnetic hyperthermia for cancer treatment. However, the development of efficient and eco-friendly methods for synthesizing SPMNPs remains a challenge. This study reports on a green synthesis approach for SPMNPs using pomegranate peel extract as a stabilizing agent. The effects of various synthesis parameters, including the type of precipitating agent (NH3 and NaOH), N2 gas, extract volume, and pH, were systematically investigated with regard to the size, morphology, and magnetic properties of the nanoparticles. The results showed that reducing the volume of the extract increased the saturation magnetization of the nanoparticles. N2 gas was found to be essential in preventing the oxidation of the nanoparticles. The type of precipitating agent also affected the size and magnetization of the nanoparticles, with NaOH leading to the synthesis of SPMNPs with higher magnetization (~ 4 times) compared to NH3. Additionally, nanoparticles synthesized at pH 10 exhibited higher magnetization than those synthesized at pH 8 and 12. In conclusion, the optimized synthesis conditions significantly affected the magnetization and stability of SPMNPs. These nanoparticles are suitable for use in magnetic nanofluid hyperthermia applications.

    Keywords: Superparamagnetic nanoparticles, Green synthesis, Pomegranate peel extract, synthesis optimization, magnetic hyperthermia

    Received: 06 Apr 2024; Accepted: 10 Jul 2024.

    Copyright: © 2024 Dehghani, Hajipour-Verdom and Abdolmaleki. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Parviz Abdolmaleki, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran

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