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ORIGINAL RESEARCH article

Front. Chem.
Sec. Polymer Chemistry
Volume 12 - 2024 | doi: 10.3389/fchem.2024.1389694
This article is part of the Research Topic Biomass sources for biopolymer manufacture for application in the drug delivery and cosmetic sectors: Current Trends and Future Perspectives View all articles

Strategies based on nido-carborane embedded indole fluorescent polymers: Their synthesis, spectral properties and cell imaging studies

Provisionally accepted
Guofan Jin Guofan Jin 1*Lei Wang Lei Wang 2Lingwei Mao Lingwei Mao 2Xibing Feng Xibing Feng 1Shuo Wang Shuo Wang 1
  • 1 Jiangsu University, Zhenjiang, China
  • 2 Zhenjiang First People's Hospital, Zhenjiang, Jiangsu Province, China

The final, formatted version of the article will be published soon.

    The continuous preparation scheme EPO-Poly-indol-nido-carborane (E-P-INDOLCAB), L100-55-Poly-indol-nido-carborane (L-P-INDOLCAB), RS-Poly-indol-nido-carborane (S-P-INDOLCAB), and RL-Poly-indol-nido-carborane (R-P-INDOLCAB) were used to prepare the four types of acrylic resin-coated nido-carborane indole fluorescent polymers. After testing their spectral properties and the fluorescence stability curve trend at various acidic pH values (3.4 and 5.5, respectively), L-P-INDOLCAB and S-P-INDOLCAB were determined to be the best polymers. The stable states of the two polymers and the dispersion of the nanoparticles on the system's surface during Atomic Force Microscope (AFM) test are shown by the zeta potentials of -23 and -42 mV. The dispersion of nanoparticles on the system's surface and the stable condition of the two polymers were examined using zeta potential and atomic force microscopy (AFM). Transmission electron microscopy (TEM) can also confirm these findings, showing that the acrylic resin securely encases the interior to form an eyeball. Both polymers' biocompatibility with HELA cells was enhanced in cell imaging, closely enclosing the target cells. The two complexes displayed strong inhibitory effects on PC-3 and HeLa cells when the concentration was 20 ug/mL, as validated by subsequent cell proliferation toxicity studies.

    Keywords: acrylic resin, nido-carborane, indole fluorescent, Eyeball, Cell imaging

    Received: 22 Feb 2024; Accepted: 26 Jun 2024.

    Copyright: © 2024 Jin, Wang, Mao, Feng and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Guofan Jin, Jiangsu University, Zhenjiang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.