AUTHOR=Yang Ying , Li Bingbing , Wang Mengxin , Pan Shicong , Wang Yu , Gu Jinhui 

TITLE=Effect of natural polymer materials on skin healing based on internal wound microenvironment: a review

JOURNAL=Frontiers in Chemistry

VOLUME=11

YEAR=2023

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2023.1257915

DOI=10.3389/fchem.2023.1257915

ISSN=2296-2646

ABSTRACT=<p>The concept of wound microenvironment has been discussed for a long time. However, the mechanism of the internal microenvironment is relatively little studied. Here, we present a systematic discussion on the mechanism of natural polymer materials such as chitosan, cellulose, collagen and hyaluronic acid through their effects on the internal wound microenvironment and regulation of wound healing, in order to more comprehensively explain the concept of wound microenvironment and provide a reference for further innovative clinical for the preparation and application of wound healing agents.</p>