AUTHOR=Kuriyama Yuse , Sasano Yusuke , Iwabuchi Yoshiharu 

TITLE=Azetidine synthesis by La(OTf)3-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines

JOURNAL=Frontiers in Chemistry

VOLUME=11

YEAR=2023

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2023.1251299

DOI=10.3389/fchem.2023.1251299

ISSN=2296-2646

ABSTRACT=<p>Azetidine is a prevalent structural motif found in various biologically active compounds. In this research paper, we report La(OTf)<sub>3</sub>-catalyzed intramolecular regioselective aminolysis of <italic>cis</italic>-3,4-epoxy amines to afford azetidines. This reaction proceeded in high yields even in the presence of acid-sensitive and Lewis basic functional groups.</p>