AUTHOR=Hootifard Ghader , Sheikhhosseini Enayatollah , Ahmadi Sayed Ali , Yahyazadehfar Mahdieh 

TITLE=Fe3O4@iron-based metal–organic framework nanocomposite [Fe3O4@MOF (Fe) NC] as a recyclable magnetic nano-organocatalyst for the environment-friendly synthesis of pyrano[2,3-d]pyrimidine derivatives

JOURNAL=Frontiers in Chemistry

VOLUME=11

YEAR=2023

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2023.1193080

DOI=10.3389/fchem.2023.1193080

ISSN=2296-2646

ABSTRACT=<p>Various pyrano[2,3-d]pyrimidines were synthesized by the multicomponent reaction of aldehydes, malononitrile, and acidic C–H compounds such as barbituric acid through the tandem Knoevenagel–Michael cyclocondensation pathway in an environmentally friendly reactive medium in the presence of a recoverable nanocomposite. This nanocomposite includes Fe<sub>3</sub>O<sub>4</sub> nanoparticles placed on an organometallic framework. The synthesized Fe<sub>3</sub>O<sub>4</sub>@iron-based metal–organic framework nanocomposite was characterized using scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray powder diffraction, a vibrating sample magnetometer, and thermogravimetric analysis.</p>