AUTHOR=Chen Huiying , Zhao Xinshuo , Cui Bingbing , Cui Haohao , Zhao Mengyang , Shi Jun , Li Jingguo , Zhou Zhan 

TITLE=Peroxidase-like MoS2/Ag nanosheets with synergistically enhanced NIR-responsive antibacterial activities

JOURNAL=Frontiers in Chemistry

VOLUME=11

YEAR=2023

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2023.1148354

DOI=10.3389/fchem.2023.1148354

ISSN=2296-2646

ABSTRACT=<p>Pathogenic microbial infections have been threatening public health all over the world, which makes it highly desirable to develop an antibiotics-free material for bacterial infection. In this paper, molybdenum disulfide (MoS<sub>2</sub>) nanosheets loaded with silver nanoparticles (Ag NPs) were constructed to inactive bacteria rapidly and efficiently in a short period under a near infrared (NIR) laser (660 nm) in the presence of H<sub>2</sub>O<sub>2</sub>. The designed material presented favorable features of peroxidase-like ability and photodynamic property, which endowed it with fascinating antimicrobial capacity. Compared with free MoS<sub>2</sub> nanosheets, the MoS<sub>2</sub>/Ag nanosheets (denoted as MoS<sub>2</sub>/Ag NSs) exhibited better antibacterial performance against <italic>Staphylococcus aureus</italic> by the generated reactive oxygen species (ROS) from both peroxidase-like catalysis and photodynamic, and the antibacterial efficiency of MoS<sub>2</sub>/Ag NSs could be further improved by increasing the amount of Ag. Results from cell culture tests proved that MoS<sub>2</sub>/Ag3 nanosheets had a negligible impact on cell growth. This work provided new insight into a promising method for eliminating bacteria without using antibiotics, and could serve as a candidate strategy for efficient disinfection to treat other bacterial infections.</p>