AUTHOR=Liu Junyang , Chen Hang , Wang Min , He Wangjin , Yan Jia-Lei TITLE=Organocatalytic asymmetric synthesis of P-stereogenic molecules JOURNAL=Frontiers in Chemistry VOLUME=11 YEAR=2023 URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2023.1132025 DOI=10.3389/fchem.2023.1132025 ISSN=2296-2646 ABSTRACT=

P-chirality broadly appears in natural and synthetic functional molecules. The catalytic synthesis of organophosphorus compounds bearing P-stereogenic centers is still challenging, due to the lack of efficient catalytic systems. This review summarizes the key achievements in organocatalytic methodologies for the synthesis of P-stereogenic molecules. Different catalytic systems are emphasized for each strategy class (desymmetrization, kinetic resolution, and dynamic kinetic resolution) with examples cited to illustrate the potential applications of the accessed P-stereogenic organophosphorus compounds.