AUTHOR=Duan Qunpeng , Chen Ran , Deng Su , Yang Cheng , Ji Xinxin , Qi Gege , Li Hui , Li Xiaohan , Chen Shihao , Lou Mengen , Lu Kui 

TITLE=Cucurbit[n]uril-based fluorescent indicator-displacement assays for sensing organic compounds

JOURNAL=Frontiers in Chemistry

VOLUME=11

YEAR=2023

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2023.1124705

DOI=10.3389/fchem.2023.1124705

ISSN=2296-2646

ABSTRACT=<p>The widespread conversion of synthetic receptors into luminescent sensors has been achieved <italic>via</italic> the use of fluorescent-indicator displacement assays (F-IDAs). Due to their rigid structures and efficient binding affinities, cucurbit[<italic>n</italic>]urils, combined with a variety of fluorescent guests, have gained extensive utilization in fluorescent-indicator displacement assays for sensing non-fluorescent or weakly fluorescent organic compounds (analytes) in a selective and specific manner. This mini-review summarizes recent advances in the design of cucurbit[<italic>n</italic>]uril-based fluorescent-indicator displacement assays and discusses the current challenges and future prospects in this area.</p>