AUTHOR=Cai Jiang Hong , Zhu Xuan Zhe , Guo Peng Yue , Rose Peter , Liu Xiao Tong , Liu Xia , Zhu Yi Zhun TITLE=Recent updates in click and computational chemistry for drug discovery and development JOURNAL=Frontiers in Chemistry VOLUME=11 YEAR=2023 URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2023.1114970 DOI=10.3389/fchem.2023.1114970 ISSN=2296-2646 ABSTRACT=

Drug discovery is a costly and time-consuming process with a very high failure rate. Recently, click chemistry and computer-aided drug design (CADD) represent popular areas for new drug development. Herein, we summarized the recent updates in click and computational chemistry for drug discovery and development including clicking to effectively synthesize druggable candidates, synthesis and modification of natural products, targeted delivery systems, and computer-aided drug discovery for target identification, seeking out and optimizing lead compounds, ADMET prediction as well as compounds synthesis, hopefully, inspires new ideas for novel drug development in the future.