AUTHOR=Dong Yun , Kong Ling-Qi , Chen Qin-Hua , Li Bin , Zeng Xiao-Hua , Ke Li-Na , Wang Hong-Mei 

TITLE=Green synthesis, crystal structure, and antifungal activities of (E)-4-arylidene-5-oxotetrahydrofuran

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.997095

DOI=10.3389/fchem.2022.997095

ISSN=2296-2646

ABSTRACT=<p>A series of γ-lactone derivatives (<italic>E</italic>)-4-arylidene-5-oxotetrahydrofuran derivatives were synthesized <italic>via</italic> a tandem Passerini 3CC/S<sub>N</sub> cyclization microwave-assisted one-pot method efficiently starting from Baylis Hillman acids, aryl glyoxals and isocyanides, and using ionic liquid as reaction medium. The products were characterized by hydrogen nuclear magnetic resonance spectroscopy (<sup>1</sup>H-NMR), carbon nuclear magnetic resonance spectroscopy (<sup>13</sup>C-NMR). Single crystal X-ray analysis of the compound RPDFB clearly confirmed its assigned chemical structures. Meanwhile, the effects of four compounds (RPDFB, RPDFC, RPDFI, RPDFJ) on the growth inhibition activity of <italic>Gibberella zeae</italic> were detected, and found that the compound RPDFB has significant growth inhibition activity to <italic>Gibberella zeae</italic>.</p>