AUTHOR=Liu Juan , Qiao Ming-Ming , Peng Cheng , Shu Hong-Zhen , Meng Chun-Wang , Liu Fei , Xiong Liang 

TITLE=Curcumanes E and F, two rare sesquiterpenoids with a dicyclo[3.3.1]nonane moiety, from Curcuma longa and their vasorelaxant activities

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.995950

DOI=10.3389/fchem.2022.995950

ISSN=2296-2646

ABSTRACT=<p>Two new sesquiterpenoids, curcumanes E (<bold>1</bold>) and F (<bold>2</bold>), were isolated from the rhizome of <italic>Curcuma longa</italic>, and their structures and absolute configurations were examined using extensive spectroscopic analyses and ECD calculations. Interestingly, compounds <bold>1</bold> and <bold>2</bold> are diastereoisomers possessing a rare sesquiterpenoid skeleton that has been reported only once before. Both curcumanes E and F exhibit significant vasorelaxant effects against KCl-induced contraction of rat aortic rings, with EC<sub>50</sub> values of 5.10 ± 0.79 and 5.58 ± 1.77 μM, respectively. These findings enrich the data concerning this rare type of sesquiterpenoids and further indicate that these rare sesquiterpenoids can effectively reduce blood pressure.</p>